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Department of Urology

Terminology

 

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Laparoscope - Small telescope.

Laparoscopy - A surgical technique in which small incisions are made in the body in order to introduce specially designed telescopes and instruments

Ligand binding domain (LBD) - The carboxy-terminal region of intracellular receptors such as androgen receptor, which binds specifically to small molecule ligands; binding to agonists triggers a conformational change that leads to LBD-coregulator interactions.

Loss of heterozygosity (LOH) - The loss of one gene allele in tumor compared to normal DNA. Genes normally have two copies (alleles).

 

 

Luteinizing Hormone Releasing Hormone (LHRH) agonist - Synthetic analogs of natural gonadotropin-releasing factor which induce a transient increase in testosterone secretion followed by fall of testosterone to castrate levels; used to treat advanced prostate cancer.

Lymph node - The main source of lymphocytes of the peripheral blood. In addition, lymph nodes serve as a defense mechanism by removing noxious agents such as bacteria, toxins and cancer cells.